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Transport of molecules across the bloodbrain barrier in a highly specific fashion via membrane receptors that become internalized with the ligand during transendothelial transcytosis
Think of it like this: a doctor needs an X-ray to confirm a broken bone before putting on a cast
The president of the United States, Donald Trump, by contrast, is everywhere at once, both literally and figuratively
Continuous exposure to any signaling molecule can lead to receptor downregulation, meaning the body responds less strongly over time
It is also where the difference between shots and pills becomes most noticeable
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