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Santiago, J
Choline is essential for phosphatidylcholine synthesis, neurotransmitter production (acetylcholine), and hepatic VLDL export
Individuals with autonomic neuropathy, including those with longstanding diabetes, may lack the sympathetic nervous system compensation needed to maintain perfusion during vasodilation
Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]
Nutrients 17 (13), 2088
