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all in-vivo evidence is from mice, and the only human-cell data is in vitro (senescent chondrocytes)
That is why plan design is becoming so important
However, based on mechanistic understanding and data from similar medications, theres no evidence of permanent metabolic impairment
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Structurally, they can be categorized into microcapsules, which consist of an API enclosed within a polymeric or lipid shell, and microspheres, in which the API is homogeneously distributed throughout the polymeric matrix [33, 34]
