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Starting with lower doses (5 grams or less) and gradually increasing intake can help minimize these effects
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1 Theres no dedicated cardiovascular outcomes trial for retatrutide yet
Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1
The prescription brand name for semaglutide is Ozempic if its prescribed for patients with type 2 diabetes
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