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Research status Investigational

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M1-like macrophages, also known as conventionally activated macrophages, are key players in pro-inflammatory responses

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Acyl-CoA synthase catalyzes the conversion of long-chain fatty acids into fatty acyl-CoAs

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65,66 A network meta-analysis ranked SEMA 0.4 mg first in the resolution of MASH among alternative treatments [surface under the cumulative ranking (SUCRA) = 0.89], higher than liraglutide (SUCRA = 0.84) and resmetirom (SUCRA = 0.44)

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