This LRRK2-ferroptosis interaction creates a pathogenic loop: ferroptosis-induced ROS is known to upregulate LRRK2 kinase activity, and the activated LRRK2 further promotes the phosphorylation of -synuclein at Ser129, which is believed to increase its neurotoxicity (Derry et al., 2020)
10.1016/j.bmcl.2011.09.047 107 WooJ
Additionally, it can help fight free radicals, reduce oxidative stress, and prevent hyperpigmentation
Both variants had similar kinetic parameters as the WT, indicating that though catalytically unchanged, the stability of these variants is markedly reduced, with G6PD Plymouth present in even lower amounts and ultimately leading to more severe clinical manifestations
BONUS: Skin Whitening (high risk) Glutathione injections can lighten your skin, which is a side effect, not their main purpose