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During chronic kidney disease (CKD), the AMPK signaling pathway is inhibited, which result in mitochondrial biogenesis (nuclear respiratory factor 1 and mitochondrial transcription factor A) as well as mitochondrial-specific proteins (cytochrome C and mitochondrial complex IV) downregulated, leading to M1 polarization of macrophages (101)
These are hypothesis-generating datasets
Pregancy Tretinoin ingestion has been known to cause birth defects
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