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126 Resistant tumors often downregulate antigen-presenting machinery, upregulate inhibitory ligands, and attract immunosuppressive cells such as regulatory T cells (T regs ) and MDSCs

Furthermore, constant 1/ 2 values for all E170X mutants (in contrast to K105X mutants) suggest that the mutation of Glu170 had no effect on a rate-limiting reduction by GSH (Fig

Apart from the inherent risks that unproven peptide therapies may pose,8 it may set a potentially dangerous precedent in which a drugs availability hinges on health market trends instead of clinical research, and could send the wrong message to the public

This means it hasn't undergone the rigorous testing required to ensure its safety and efficacy

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