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b , The alternation of surface mainly derived from an outstanding conformational change of the loop between Pro124 and Ala133, with which the side chains of Arg152 formed multiple hydrogen bonds in the wild-type, but not His152 in the mutant

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Author contributions MvH, TAB, CB, and TBJ designed the trial

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Tom Elliott, medical director of BC Diabetes, told Global News

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Fatima Cody Stanford, an obesity medicine physician-scientist at Massachusetts General Hospital

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Tsuchiya Y, Nakajima M, Yokoi T

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