A parallel line of work frames Alzheimers disease as a state of central insulin resistance, sometimes called type 3 diabetes, in which GLP-1R agonism restores neuronal insulin signalling, improves mitochondrial function, and reduces oxidative stress
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Overall, GLP-1 agonists are safe with the most common side effects of nausea, vomiting, diarrhoea and constipation being only mild to moderate in severity in most people
Additionally, the infusion of native human GIP (142) into cardiac myocytes isolated from embryonic mouse hearts inhibited the increase in brain natriuretic peptide (BNP) and transforming growth factor- (TGF- 1) mRNA expression induced by angiotensin II (Ang II) [13]
Morbidly obese patients still appear to be utilizing both options for treatment, using a GLP-1 for initial weight loss but then still requiring surgery for more complete weight loss