DNAzyme cleavage of CAG repeat RNA in polyglutamine diseases
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Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years
Comparing the AR group with the other groups, a significant decrease in total antioxidant capacity (TAC) levels and an increase in IgE, IL-5, IL-13, and total oxidant status (TOS) levels in thymol group were observed ( 3.4.6 Tussilagone Tussilagone is a sesquiterpenoid isolated from Farfarae Flos, the dried flower buds of Tussilago farfara L
doi: 10.3389/fimmu.2025.1634516 Received 24 May 2025 Accepted 30 June 2025 Published 16 July 2025 Volume 16 - 2025 Edited by Qi Feng, First Affiliated Hospital of Zhengzhou University, China Reviewed by Yufeng Yao, Huazhong University of Science and Technology, China YangYang, First Affiliated Hospital of Zhengzhou University, China Updates Copyright 2025 Xiao, Han, Jia, Li, Gong, Cai, Pang, Ye and Jin