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This pharmacokinetic difference is a key factor when designing research protocols

Prevailing models propose that plant vacuolar sorting receptors (VSRs) recycle either from multivesicular bodies (MVBs) to the trans-Golgi network (TGN) or from the TGN to the Golgi apparatus and/or endoplasmic reticulum (ER)

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Because oral L-carnitine is only about 15% absorbed, the unabsorbed remainder passes into the lower gut, which is part of why higher oral doses drive more GI complaints