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Gabrielle Lyon Founder Institute for Muscle-Centric Medicine Dr
The peptide backbone is modeled after the native GIP sequence, heavily modified with specific amino acid substitutions and conjugated to a C20 fatty diacid side chain via a hydrophilic spacer
In a body composition substudy in people with type 2 diabetes and obesity (PMID: 40609566), retatrutide produced a lean mass loss of about 38% of total weight loss, which falls within the 2040% range reported for other GLP1based therapies such as semaglutide and tirzepatide (see PMID: 40609564
& Mller, G
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