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Insulin therapy can be simplified by reducing the number of insulin units and switching to once-daily basal analogue insulin, once-weekly GLP-1 receptor agonists, or a combination of basal insulin and GLP-1 receptor agonists [254]

The daily dosing schedule of the ODT versus weekly injection is a trade-off

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Here, we demonstrate that a peptideantibody conjugate that blocks GIPR while simultaneously activating GLP-1R (GIPR-Ab/GLP-1) requires both CNS GIPR and CNS GLP-1R for maximal weight loss in obese, primarily male, mice

Cabeza, R