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Human studies have demonstrated good outcomes for weight reduction in people with ( 2.62 kg) and without ( 5.09 kg) T2D over 4 weeks compared with placebo [50]

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Whole root granules of 12,000 mg/day (equivalent to 6,000 mg of root powder) have also been used (ODS 2023)

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The deacetylation of SHMT2 at K95 by SIRT3 (Wei et al., 2018) or desuccinylation at K280 by SIRT5 (Yang et al., 2018) has been shown to enhance the enzymatic activity of this protein, and the deacetylation by SIRT3 also has been shown to stabilize SHMT2 through avoiding its autophagic degradation (Wei et al., 2018)