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303 These compounds also reduce CSC populations and remodel the TME to enhance immune cell infiltration and activity
Its biological output is dynamically tuned by therapeutic modality, microenvironmental redox conditions, post-transcriptional regulation (e.g., miR-23a-3p and miR-145-5p), post-translational modification (e.g., SIAH2-mediated ubiquitination), and substrate flux partitioning
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