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The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin.Journal of Theoretical Biology

Importantly, chronic administration over 4 weeks translated this acute secretory boost into sustained metabolic benefits, including attenuated weight gain and food intake, improved glucose tolerance, and enhanced insulin sensitivity, which were consistent with the effects of elevated GLP-1 ( In this study, we did not perform a comprehensive pharmacokinetic analysis since the absorption and disposition of Hesperetin and Naringenin have been extensively characterized elsewhere ( in vitro assays ( Overall, our findings not only provide a mechanistic basis for the purported antidiabetic benefits of citrus bioactive but also highlight these flavonoids as promising candidates for the development of nutraceutical or therapeutic agents aimed at enhancing endogenous GLP-1 secretion

PMID: 21119085

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Females, younger adults, and people with conditions like chronic kidney disease or heart failure tended to report more GI symptoms