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362 In an experimental study in which osteoclast formation and bone resorption were induced in mice through lipopolysaccharide (LPS) administration, researchers discovered that simultaneous treatment with exendin-4 resulted in a significant decrease in the number of osteoclasts, the proportion of bone resorption pits, and the levels of the bone resorption marker CTX compared to injection with LPS alone
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STEP 5 Two-Year Safety Results In the STEP 5 trial involving 304 participants (152 receiving semaglutide, 152 receiving placebo), gastrointestinal adverse events occurred in 82.2% of the semaglutide group versus 53.9% of the placebo group over the two-year period
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