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Patients in large clinical trials for GLP-1s lost an average of 15% to 20% of their body weight, depending on the drug they were given
Their average weight decreased from 87.9 kg before treatment to 74.1 kg during the weekly injection phase, and further decreased slightly to 72.4 kg after extending the interval
Millions have experienced significant health benefits from these drugs, ranging from improved blood sugar control to substantial weight reduction
mild diarrhea was the only dose-limiting toxicity (Sharma et al., 2004)
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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