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Mitochondrial endpoints include ATP/ADP ratio, membrane potential, oxygen-consumption rate, extracellular-acidification rate, and mitophagy markers [8, 31,32,33,34,35]

The role of MOTS-c in humans will need larger controlled trials

Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells

Tirzepatide before and after data from clinical trials suggests the lean mass loss percentage may be lower than with some other interventions, but it is still a legitimate concern

Congratulations to the SEAL team, lead by our own Jordanian American Physician Osama Z., and investigators for this important milestone