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9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution
Lixisenatide and exenatide are much weaker GLP-1 drugs compared with semaglutide, tirzepatide and several others that are in clinical trials as shown below for weight loss
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For example, Eli Lilly recently reduced the price of Zepbound due to increased competition
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