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Risks, Side Effects & Safety Common Side Effects: Nausea (dose-dependent) Facial flushing Increased libido Long-term pigmentation changes Darkening of moles or freckles (monitor with provider) Contraindications : Not for individuals with a history of melanoma or skin cancer

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Neurotrophins such as BDNF and NGF play central roles in synaptic plasticity, neuronal survival, and network organization, and their dysregulation may represent a more proximal mechanism underlying behavioral impairments

3.4.6 TAM family of receptor tyrosine kinases The increase in CORT induced by stress also activates the GR-MERTK signaling pathway in astrocytes, leading to heightened phagocytosis of excitatory synapses by astrocytes in cortical regions, thereby eliciting depressive behavior in mice (255)