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Rescue is possible but problematic since the pink curve descends somewhat below 30%

It is extrapolated from animal data and community experimentation, not from a human dose-finding trial

Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver

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Kaplan Meier Overall survival (OS) of patients split based on ssGSEA scores for Glycolysis ( a ) and Fatty Acid (FA) metabolism ( b ) signatures, with Log rank test and Hazard Ratio analyses reported