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Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses

These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

Hydration becomes more important, especially if appetite drops or digestive side effects appear

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