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549 Impaired oxidation of NADH, a function of respiratory complex I, increases NADH levels, driving the equilibrium toward lactate accumulation, which differs from the proportional increase in lactate and pyruvate seen in pyruvate dehydrogenase deficiency
In one study, mice treated with 20mg/kg of 5-amino-1mq three times daily for 11 days experienced a 5.1% reduction in body weight from baseline
10.1186/s12864-021-08159-z BMC Genomics
Additionally, its role in regulating certain amino acids helps to protect the heart, further supporting circulation across the body
doi: 10.1074/jbc.M301426200 127
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