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GLP-1 receptor agonists alone do not represent cures for obesity.(24) The weight lowering effects appear to persist only as long as the medication is taken consistently and at the full therapeutic dose
Mannino, G., Gentile, C., Ertani, A., Serio, G
Research study looking at how well semaglutide tablets taken once daily works in people who have a body weight above the healthy range (OASIS 4)
Thus, the glycolysis pathway would be downregulated and gluconeogenesis would be upregulated
Clinical trials demonstrate that GLP-1 weight loss medications, when combined with lifestyle modifications, can produce 15-20% total body weight loss over 52 weeks
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