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It differs from native IGF-1 at two positions: a 13-amino-acid N-terminal extension and substitution of arginine for glutamate at position 3
Tirzepatide works partly by enhancing insulin secretion when blood sugar rises
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Regarding drug interactions, while semaglutide has few direct interactions affecting its elimination, patients should be aware of two important considerations: 1) Monitor INR more frequently when initiating semaglutide in patients taking warfarin, and 2) Increased levothyroxine exposure may occur with oral semaglutide (Rybelsus), requiring monitoring of thyroid function tests
Endocrinology 142 (5), 18201827
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