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Remodeling enzymes
4 p.m
In its role as a precursor for the formation of acetylcholine (an important neurotransmitter), this compound helps maintain cognitive functions
Patients (76% males, 89% Caucasian, 93% enrolled at US sites, 89% with a history of angina, 52% without PCI, 4% with PCI and no stent, and 44% with a stent) were randomized to double-blind treatment with either amlodipine besylate (5 to 10 mg once daily) or placebo in addition to standard care that included aspirin (89%), statins (83%), beta-blockers (74%), nitroglycerin (50%), anti-coagulants (40%), and diuretics (32%), but excluded other calcium channel blockers
This high dropout rate is a feature of early-phase dose-finding studies with aggressive escalation it doesnt necessarily predict Phase 3 retention
