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doi: 10.1016/j.pharmthera.2022.108270 42 GoEJHwangS-MJoHRahmanMMParkJLeeJYet al
It is known that the CV protection effect of GLP-1RAs have been proven through eight large-scale clinical studies, including Evaluation of LIXisenatide in Acute coronary syndrome (ELIXA) [66], LEADER [44], Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN)-6 [67], Exenatide Study of Cardiovascular Event Lowering (EXSCEL) [68], Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes) [69], Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) [70], Peptide Innovation for Early Diabetes Treatment (PIONEER) 6 [67,71], and AMPLITUDE-O [51]
These disruptions include a reduction in SCFA producers and an increase in bacteria associated with inflammation and metabolic endotoxemia, which may serve as potential biomarkers for disease progression and severity
Immunity 52, 5581
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