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TB-500: The Inflammation Controller TB-500 is a synthetic fragment of thymosin beta-4, a peptide naturally produced by the thymus gland

Broad Institute Connectivity Map analysis shows it influences approximately 6% of the human genome making this one of the most broadly active signaling peptides in published research

Activation of these receptors in the brain (particularly brainstem and hypothalamic regions) suppresses appetite, reduces food intake through both homeostatic and hedonic pathways, slows gastric emptying to prolong fullness, and inhibits postprandial glucagon release to aid glucose control

Samples were fixed in 10% buffered formalin overnight at 4C, dehydrated with increasing concentrations of ethanol, embedded in paraffin, cut into 5 m sections, and stained with hematoxylin and eosin (HE) or Massons Trichrome Stain Kit (Sigma-Aldrich)