The details of the methylmalonic acidurias are covered in the Methylmalonic Acidemias/Acidurias page
They assumed that improvements in endothelial function with GLP-1R agonists might be limited to the postprandial setting, particularly following the consumption of a high-fat meal [60]
PI3K/Akt/mTOR and MAPK/ERK Pathway Activation In research settings, IGF-1 LR3 activates the PI3K/Akt pathway (involved in survival, glucose metabolism, and protein synthesis), the RAS/MAPK pathway (regulating growth and differentiation), the mTOR pathway (governing anabolic protein synthesis signalling), and IRS-1/2 cross-talk with insulin receptor signalling the full complement of IGF-1R-mediated downstream effects
A safe obesity treatment that slows digestion and curbs cravings Extenatide was the very first GLP-1-mimicking drug
N Engl J Med 392:427437 le Roux CW, Astrup A, Fujioka K et al (2017) 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial