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2001, Lipinski 2004, Abrahamsson and Lennernas 2005)
The Copenhagen trial measured circulating biomarkers but did not perform tissue biopsies, so we don't know whether NNMT suppression in non-adipose tissues produces structural or functional changes over time
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At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance
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