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Presynaptically, BDNF increases glutamate release, thus enhancing the frequency of miniature excitatory postsynaptic currents (mEPSCs) in hippocampal neurons [16, 24]
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Coupled with selection of proper linker structure and payload, this method can potentially lead to ADCs with enhanced PK/PD and therapeutic efficacy
System x c and thioredoxin reductase 1 cooperatively rescue glutathione deficiency
This suggests that targeted therapy aimed at Gln metabolism may represent a novel and potentially effective strategy for cancer patients
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