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Cho SY, Oh Y, Jeong EM,Park SLD, Gong H,Liu X, Zhang G, Na D,Lee J, Chae J

More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

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The biofilm layer of PAO1 and indicated strains was stained with 1% crystal violet solution