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doi: 10.1016/j.esxm.2020.100298
Some evidence suggests that weight loss itself affects thyroid function
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Abbreviations SGLT-2i: Sodium-dependent glucose transporters 2 inhibitors GLP-1 Ras: Glucagon-like peptide 1 COVTs: Cardiovascular outcomes trials MACE: Major adverse cardiovascular events HHF: Hospitalization for heart failure CV death: Cardiovascular death HHF or CV death: Hospitalization for heart failure or cardiovascular death MI: Myocardial infarction T2DM: Type 2 diabetes mellitus RoB 2: Risk-of-bias tool CIs: Confidence intervals HRs: Hazard ratios References Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, et al
For instance, diabetes-induced chronic hyperglycemia, persistently-elevated free fatty acids and hyperinsulinemia all could lead to cardiac hypertrophy, intramyocardial inflammation, impaired mitochondrial function, and ultimately HF [4]
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