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The informative design compares four arms at matched concentrations: the complex, the free tripeptide, a simple copper salt, and vehicle
Typically, MRP, OATP, BCRP and OAT transporters will efflux glucuronides
doi: 10.1159/000115717
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Bioavailability limitations require 2-3x higher doses for nasal versus injectable delivery , creating corresponding 2-3x cost increases that make nasal spray primarily appropriate for needle-phobic individuals or peptides specifically designed for nasal use
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