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The typical elevation of 1-4 beats per minute falls within normal physiological variation and is comparable to the heart rate changes seen with routine daily activities

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The incidence of vomiting was 13% with dulaglutide at 1.5 mg, 8% at 0.75 mg, and 2% with sitagliptin

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As a consequence of obesity, up to 50% of patients are affected by MetS, with insulin resistance up to of 77% regardless of disease duration, predisposing patients to type 2 diabetes mellitus and hypertension [28] (Fig