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Supporting the crucial role of W33, PF-06882961 increased cAMP accumulation in cells expressing the S33W mutant of mouse GLP-1R, whereas it failed to induce signaling at the human W33S receptor (Fig
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Of note, a US national survey (NHANES III) reported that over 99% of the US participants had serum selenium concentrations consistent with selenium requirements being met (65), suggesting selenium supplementation is not needed for most Americans
Both estimands were used for the primary treatment period analysis for primary and secondary endpoints, unless specified otherwise
