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[3] NNMT sits at an intersection of two important resource pools: it consumes SAM (the cells universal methyl donor) and it draws on nicotinamide that would otherwise feed the NAD salvage pathway
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How This Affects Your B12 Needs Deciding between vitamin B12 oral vs injection comes down to how well your body absorbs them, the symptoms you experience, and your personal health goals
If you decide to undertake self-injection, first consult a nurse practitioner or doctor to learn the proper method of identifying and cleaning the injection site, administration and how-to properly open and clean a vial.
Mechanism Selective NNMT inhibition, proposed to preserve intracellular NAD+/SAM and reduce fat-cell lipogenesis demonstrated in mice, not humans
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