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Collectively, these discoveries demonstrate that -T3 induces structural and functional abnormalities in the mitochondria of CRPC cells, leading to cell death
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Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig
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What is mannitol-free NAD+ and why is it used
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