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Some of the symptoms of a vitamin B12 deficiency may include: Fatigue Weakness Memory loss Cognitive functioning problems Diarrhea or constipation Loss of appetite Shortness of breath Beefy, red, smooth and sore tongue Sore mouth and/or bleeding gums Numbness and tingling of hands and feet Poor sense of balance Depression Confusion Insomnia Vision problems Loss of hearing and tinnitus Pale, possibly yellowish pallor in light-skinned individuals

*Correspondence: Weina Li, [email protected] Meng Li, [email protected] These authors have contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Addressing the problem while tissue retains regenerative capacity offers better outcomes than waiting until degeneration becomes established

Cultured against USP standards