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As humans do not produce TMCA, we examined the levels of non-12-OH FXR-antagonistic BA species in humans, and found that the levels of non-12-OH FXR-antagonistic BAs (HDCA and UDCA-related species) were positively correlated with T3 levels in euthyroid human study participants (Fig
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It mimics the actions of the naturally occurring GLP-1 hormone, which stimulates insulin secretion, reduces appetite, and slows gastric emptying
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