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Some of the medications that can interact with Wegovy (semaglutide) include antimalarials (chloroquine), other diabetes drugs, aspirin, acetaminophen, blood pressure medications such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), calcium channel blockers, diuretics (water pills), certain antibiotics (clarithromycin, amoxicillin), androgens, skeletal muscle relaxants (carisoprodol), HIV medications, antipsychotic drugs, and antiepileptic drugs
The medication also offers a certain degree of kidney protection