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Humans express three isoforms of PIP4K identified as phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K encoded by the PIP4K2A gene), phosphatidylinositol-5-phosphate 4-kinase type 2 beta (PIP4K encoded by the PIP4K2B gene), and phosphatidylinositol-5-phosphate 4-kinase type 2 gamma (PIP4K encoded by the PIP4K2C gene)

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It is a unique molecule that acts as a tri-agonist for the GIP, GLP-1, and GCG receptors