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In the activated hPSC cell line, both GSH and SB431542 significantly down-regulated the TGF1/SMAD pathway and the expression of -SMA under high glucose conditions

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Therefore, compared to other forms like Setria L-glutathione, its efficacy remains a matter of ongoing research and debate

The cells incorporate cysteine and most of the intracellular cysteine is incorporated into the synthesis of GSH