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By increasing the dose too rapidly the likelihood of side effects increases
These co-agonists have been shown to reduce glucose levels and body weight in people with overweight/obesity and type 2 diabetes, with nausea and vomiting the most frequently detected side effects (reviewed in [80, 81])
Patients with high visceral fat, insulin resistance, stubborn abdominal fat that does not respond to diet and exercise, and low lean muscle mass tend to respond best
Szapary PO, Wolfe ML, Bloedon LT, et al
However, the relationship between the two is even more interesting than a simple "contains" or "doesn't contain" label
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