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According to a 2017 systematic review in the Journal of Clinical Nursing confirming that aspiration before subcutaneous injection does not reduce adverse events, subcutaneous injections carry a distinct pharmacokinetic profile that intramuscular delivery disrupts, which is why correct angle and depth matter for predictable results
Beyond GI AEs, semaglutide was found to associate with a higher incidence of gallbladder-related disorders, primarily cholelithiasis [13, 40, 42, 44,45,46], and acute pancreatitis [13, 39, 42, 44] compared with placebo