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Many people find that their digestive system needs time to adjust to these new hormonal signals

Generally, GLP-1s are well tolerated and dont appear to cause severe adverse events in most people, particularly semaglutide

(3,4) According to recent research, patients can see weight loss ranging from 16.5% to 22.4% of their initial body weight after committing to tirzepatide for 72 weeks

Kitzman DW, Lam CSP (2017) Obese heart failure with preserved ejection fraction phenotype: from pariah to central player

It should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis, as it is not a substitute for insulin in these conditions