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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

Pharmaceutical-grade pre-filled pens (Ozempic, Wegovy, Mounjaro, Zepbound) Different rules apply for pharma products: Ozempic pen: 56 days after first use (per FDA label) Wegovy pen: 28 days after first use Mounjaro/Zepbound pen: 28 days after first use Why longer: Pharmaceutical formulations include additional stabilizers not present in research peptides

SURMOUNT arthralgia rates match placebo

General guidance from MedlinePlus recommends changing sites from one injection to the next and spacing new injections at least 1 inch away from the previous spot

Suzuki K, Okada H, Takemura G, Takada C, Tomita H, Yano H, Muraki I, Zaikokuji R, Kuroda A, Fukuda H, Nishio A, Takashima S, Suzuki A, Miyazaki N, Fukuta T, Yamada N, Watanabe T, Doi T, Yoshida T, Kumada K, Ushikoshi H, Yoshida S, Ogura S