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Sermorelin and tesamorelin both have histories as FDA-approved compounds for specific clinical contexts, while ipamorelin has only ever been studied as a research compound and is not approved for human use
A.NewtonS
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Patients with predominant metabolic or obese phenotypescharacterized by insulin resistance and central adipositymay derive the greatest benefit from GLP-1 receptor agonists in combination with metformin, leveraging the synergistic effects of appetite suppression and enhanced insulin sensitivity
Sharma SK et al
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